Does melatonin interact with estrogen, progesterone or testosterone?Updated a day ago

Considerations depend on your specific situation.  As always, we recommend consulting your healthcare practitioner for any questions or concerns you may have regarding this product.

Estrogen increases melatonin blood levels.  Using melatonin with oral or transdermal estrogen can therefore increase exposure and impact.  Transdermal estrogen has a milder interaction with melatonin levels compared to oral estrogen because it bypasses first-pass liver metabolism.  Those taking estrogen may need to monitor how they feel when adding melatonin to their nightly routine.

Progesterone is sleep-promoting, with no significant metabolic interaction with melatonin. As progesterone helps with sleep, many people may require less melatonin when taking it.

Testosterone is compatible with melatonin at standard doses (0.3-3mg).

Everyone responds to melatonin differently. Starting with a half-dose can help ascertain next-day feel/grogginess.  If you start with a whole serving and experience next-day grogginess, reducing to a half-serving may help alleviate the issue.  

Product Directions:

Adults take 2 capsules 1-2 hours before bedtime, at roughly the same time each night. New to melatonin or sensitive? Start with ½ serving for 3–4 nights, then increase to 1 serving as needed. If you experience next-day grogginess, consider taking it earlier or reducing the serving to ½. Do not exceed suggested use.